The book sets an ambitious goal. It devises a new account of scientific methodology that makes it possible to explain how scientists manage, at least occasionally, to find true models of reality. The new methods may be contrasted with all those currently available that employ “coherence theories” of knowledge. Under this designation are grouped positions that can seem very different (such as those of Poincaré, Duhem, Popper, Hempel, Quine, Kuhn, and Feyerabend) but are united by the idea that the most (...) general statements of science are merely hypotheses. They may be conjectures, opinions, conventions, posits, paradigms, or even myths. The most we can claim to know from such generalities is that they are internally consistent and coherent with empirical data. Consistency is insufficient to establish the truth of a conceptual system because many different systems, perhaps an infinite number, can be logically consistent and cohere with recorded data. Such is the well-known problem of the empirical under-determination of theories. Francis Bacon’s Skeptical Recipes for New Knowledge suggests a new methodology that solves this fundamental problem of knowledge. (shrink)

Comparative study of Indic philosophies from pre-Vedic times to the present day.

pt. 1. [without special title] -- pt. 2. The eternal world drama.

Development of the Physicist's Conception of Nature P. A. M. Dime When one looks back over the development of physics, one sees that it can be pictured as a ...

Karl Popper and Thomas Kuhn were friends of science because they shared some values—the value of science for humanity, especially. My thesis is that their different accounts of science could not sa...

Julian Schwinger was one of the leading theoretical physicists of the twentieth century. His contributions are as important, and as pervasive, as those of Richard Feynman, with whom he shared the 1965 Nobel Prize for Physics. Yet, while Feynman is universally recognized as a cultural icon, Schwinger is little known even to many within the physics community. In his youth, Julian Schwinger was a nuclear physicist, turning to classical electrodynamics after World War II. In the years after the war, he (...) was the first to renormalize quantum electrodynamics. Subsequently, he presented the most complete formulation of quantum field theory and laid the foundations for the electroweak synthesis of Glashow, Weinberg, and Salam, and he made fundamental contributions to the theory of nuclear magnetic resonance, to many-body theory, and to quantum optics. He developed a unique approach to quantum mechanics, measurement algebra, and a general quantum action principle. His discoveries include 'Feynman's' parameters and 'Glauber's' coherent states; in later years he also developed an alternative to operator field theory which he called Source Theory, reflecting his profound phenomenological bent. His late work on the Thomas-Fermi model of atoms and on the Casimir effect continues to be an inspiration to a new generation of physicists. This biography describes the many strands of his research life, while tracing the personal life of this private and gentle genius. (shrink)

N‐type inactivation of potassium channels is controlled by cytosolic loops that are intrinsically disordered. Recent experiments have shown that the mechanism of N‐type inactivation through disordered regions can be stereospecific and vary depending on the channel type. Variations in mechanism occur despite shared coarse grain features such as the length and amino acid compositions of the cytosolic disordered regions. We have adapted a phenomenological model designed to explain how specificity in molecular recognition is achieved through disordered regions. We propose that (...) the channel‐specific observations for N‐type inactivation represent distinct mechanistic choices for achieving function through conformational selection versus induced fit. It follows that the dominant mechanism for binding and specificity can be modulated through subtle changes in the amino acid sequences of disordered regions, which is interesting given that specificity in function is realized in the absence of autonomous folding. (shrink)

Authoritarian governments are characterised by political systems with concentrated and centralised power. Healthcare is a critical component of any state. Given the powers of an authoritarian regime, we consider the opportunities they possess to derive good health outcomes. The 2019 Varsity Medical Ethics Debate convened on the motion: ‘This house believes authoritarian government is the route to good health outcomes’ with Oxford as the Proposition and Cambridge as the Opposition. This article summarises and extends key arguments made during the 11th (...) annual debate between medical students from the Universities of Oxford and Cambridge. By contrasting the principles underlying authoritarianism and democracy, it enables a discussion into how they translate into healthcare provision and the outcomes derived. Based on the foundation of said principles, an exploration of select cases represents examples of applications and the results. We analyse the past, present and future implications on the basis of fundamental patient-centred care. (shrink)

In this paper, the main outlines of the discussions between Niels Bohr with Albert Einstein, Werner Heisenberg, and Erwin Schrödinger during 1920–1927 are treated. From the formulation of quantum mechanics in 1925–1926 and wave mechanics in 1926, there emerged Born's statistical interpretation of the wave function in summer 1926, and on the basis of the quantum mechanical transformation theory—formulated in fall 1926 by Dirac, London, and Jordan—Heisenberg formulated the uncertainty principle in early 1927. At the Volta Conference in Como in (...) September 1927 and at the fifth Solvay Conference in Brussels the following month, Bohr publicly enunciated his complementarity principle, which had been developing in his mind for several years. The Bohr-Einstein discussions about the consistency and completeness of qnautum mechanics and of physical theory as such—formally begun in October 1927 at the fifth Solvay Conference and carried on at the sixth Solvay Conference in October 1930—were continued during the next decades. All these aspects are briefly summarized. (shrink)

This paper deals with the development of, and the current discussion about, the interpretation of quantum mechanics. The following topics are discussed: 1. The Copenhagen Interpretation, 2. Formal Problems of Quantum Mechanics, 3. Process of Measurement and the Equation of Motion, 4. Macroscopic Level of Description, 5. Search for Hidden Variables, 6. The Notion of “Reality” and Epistemology of Quantum Mechanics, 7. Quantum Mechanics and the Explanation of Life.The Bohr‐Einstein dialogue on the validity of the quantum mechanical description of physical (...) reality lasted over two decades. Since the early nineteen fifties, Wiper has provided much of the point and counterpoint of the continuing discussion on the interpretation and epistemology of quantum mechanics. We have explored Wiper's views in some detail against the background of historical development and current debate. (shrink)

There are complex considerations when planning to disclose an attenuated psychosis syndrome diagnosis. In this review, we evaluate ethical, legal, and clinical perspectives as well as caveats related to full, non- and partial disclosure strategies, discuss societal implications, and provide clinical suggestions. Each of the disclosure strategies is associated with benefits as well as costs/considerations. Full disclosure promotes autonomy, allows for the clearest psychoeducation about additional risk factors, helps to clarify and/or correct previous diagnoses/treatments, facilitates early intervention and bolsters communication (...) between providers but there are important considerations involving heritability, comorbidity, culture, and stigma. Non-disclosure advances nonmaleficence by limiting stigma and stress, and confusion in a sensitive developmental period but is complicated by varying patient preferences and the possibility that, as new treatments without adverse effects become available, the risk with false positives no longer justifies the accompanying loss of autonomy. Partial disclosure balances ethical considerations by focusing on symptoms instead of labels, but evidence that laypersons may interpret this information as a pseudo-diagnosis and that symptoms alone also contribute to stigma limits the efficacy of this approach. In addition, there are notable societal considerations relating to disclosure involving conservatorship, the reach of insurance companies, and discrimination. We advocate a hybrid approach to disclosure and recommend future research aimed at understanding the effects of stigma on clinical course and a renewed focus on those help-seeking cases that do not transition but remain clinically relevant. (shrink)

This paper deals with the development of, and the current discussion about, the interpretation of quantum mechanics. The following topics are discussed: 1. The Copenhagen Interpretation, 2. Formal Problems of Quantum Mechanics, 3. Process of Measurement and the Equation of Motion, 4. Macroscopic Level of Description, 5. Search for Hidden Variables, 6. The Notion of “Reality” and Epistemology of Quantum Mechanics, 7. Quantum Mechanics and the Explanation of Life.The Bohr‐Einstein dialogue on the validity of the quantum mechanical description of physical (...) reality lasted over two decades. Since the early nineteen fifties, Wiper has provided much of the point and counterpoint of the continuing discussion on the interpretation and epistemology of quantum mechanics. We have explored Wiper's views in some detail against the background of historical development and current debate. (shrink)

In this study, I discuss the development of the ideas of Josiah Willard Gibbs' Elementary Principles in Statistical Mechanics and the fundamental role they played in forming the modern concepts in that field. Gibbs' book on statistical mechanics became an instant classic and has remained so for almost a century.

This article is in three parts. Part I gives an account of Erwin Schrödinger's growing up and studies in Vienna, his scientific work—first in Vienna from 1911 to 1920, then in Zurich from 1920 to 1925—on the dielectric properties of matter, atmospheric electricity and radioactivity, general relativity, color theory and physiological optics, and on kinetic theory and statistical mechanics. Part II deals with the creation of the theory of wave mechanics by Schrödinger in Zurich during the early months of 1926; (...) he laid the foundations of this theory in his first two communications toAnnalen der Physik. Part III deals with the early applications of wave mechanics to atomic problems—including the demonstration of equivalence of wave mechanics with the quantum mechanics of Born, Heisenberg, and Jordan, and that of Dirac—by Schrödinger himself and others. The new theory was immediately accepted by the scientific community. (shrink)

This article (Part II) deals with the creation of the theory of wave mechanics by Erwin Schrödinger in Zurich during the early months of 1926; he laid the foundations of this theory in his first two communications toAnnalen der Physik. The background of Schrödinger's work on, and his actual creation of, wave mechanics are analyzed.

This article (Part III) deals with the early applications of wave mechanics to atomic problems—including the demonstration of the formal mathematical equivalence of wave mechanics with the quantum mechanics of Born, Heisenberg, and Jordan, and that of Dirac—by Schrödinger himself and others. The new theory was immediately accepted by the scientific community.

In this series of articles the early life and work of the young Julian Schwinger are explored. In the present article, we discuss Schwinger's winding up his work at the MIT Radiation Laboratory, being offered a tenured professorship at Harvard University, getting married, and settling down into a highly productive teaching and research career.

In this series of articles the early life and work of the young Julian Schwinger is explored. After a brilliant beginning at Columbia University, where he received his Ph.D., Schwinger went to work with J. Robert Oppenheimer in Berkeley. His stay, work, and interactions with Oppenheimer are discussed.

In this series of articles the early life and work of the young Julian Schwinger are explored. In this first article, Schwinger's childhood, growing-up, and early education are discussed.

In this series of articles the early life and work of the young Julian Schwinger are explored. In the present article, Schwinger's work at the MIT Radiation Laboratory during the Second World War is described.

In this series of articles the life and work of the young Julian Schwinger are explored. In this second article in the series, Schwinger's work at Columbia University, up to the completion of his doctorate and a little after, is discussed. Schwinger soon matured into a brilliant theoretical physicist.

Contributed articles, chiefly on Indic philosophy; festschrift honoring the Indian philosopher and educator Satewan Parsram Kanal.